We are looking for an undergrad student to work with us starting this summer or fall.
Biosafety regulations do not permit undergrads in the BSL-3 lab but we have opportunities for experience in our BSL-2 lab.
Contact me for information.
Openings available
We have openings for a Research III and Research IV tech position.
I will also be taking rotation PhD students in the fall of 2022.
See Opportunities for more information!
Two new preprints are up on BioRXIV
2022 has been busy, hence I haven’t posted an update in a while….but here is a free picture of Nacho!
And two manuscripts we’ve been working hard on!!
Oropouche orthobunyavirus infection is mediated by the cellular host factor Lrp1
Madeline M. Schwarz, David A. Price, Safder S. Ganaie, Annie Feng, Nawneet Mishra, Ryan M. Hoehl, Farheen Fatma, Sarah H. Stubbs, Sean P.J. Whelan, Xiaoxia Cui, Takeshi Egawa, Daisy W. Leung, Gaya K. Amarasinghe, Amy L. Hartman
bioRxiv 2022.02.26.482111; doi: https://doi.org/10.1101/2022.02.26.482111
Cynthia M. McMillen, Devin A. Boyles, Stefan G. Kostadinov, Ryan M. Hoehl, Madeline M. Schwarz, Joseph R. Albe, Matthew J. Demers, Amy L. Hartman
bioRxiv 2022.02.25.481831; doi: https://doi.org/10.1101/2022.02.25.481831
Seeking motivated team members!
We have several openings in the lab for research technicians, post-docs, or staff scientists. Please don’t hesitate to reach out to me directly if you are interested!
Lrp1: New host factor for Rift Valley fever virus infection
A major study of ours was just published in Cell, with a fabulous Leading Edge review written about the study. We had no idea that Cell was soliciting a review, so this was a complete surprise!
You can read my synopsis of our work and how it came about in my twitter thread here.
This was such an interesting journey from meeting Dr. Gaya Amarasinghe at NSV2018 to publication! Lots of individuals contributed over the years at several institutions and I’m super proud of this work. I’m also glad we can talk about it! The Lrp1 story has turned into a major effort in our lab and has cross-cutting implications for all of our projects.
Gaya and Amy at the Negative Strand Virus (NSV) Conference in 2018. This was the genesis of the Lrp1 project!
Ganaie, S.S., M.M. Schwarz, C.M. McMillen, D. Price, A. Feng, J.R. Albe, W. Wang, S. Miersch, A. Ovredahl, A.R. Cole, M.F. Sentmanat, N. Mishra, D.A. Boyles, Z.T. Koenig, M.R. Kujawa, M.A. Demers, R.M. Hoehl, A. Moyle, N. Wagner, S.H. Stubbs, L. Cardarelli, J. Teyra, A.K. McElroy, M.L. Gross, S.P.J. Whelan, J. Doench, X. Cui, T.J. Brett, S.S. Sidhu, H.W. Virgin, T. Egawa, D.W. Leung, G.K. Amarasinghe, and A.L. Hartman. Lrp1 is a host entry factor for Rift Valley Fever Virus. Cell. Published online 23 September 2021.
New Pre-Print is posted
We have a new pre-print on BioRXIV. This is the companion paper to the EEEV paper we published earlier this year. Huge collaborative effort between Klimstra, Reed, and Hartman labs in the Pitt CVR.
“Long-term persistence of viral RNA and inflammation in the CNS of macaques exposed to aerosolized Venezuelan equine encephalitis virus,”
Henry Ma, Joseph R. Albe, Theron Gilliland, Cynthia M. McMillen, Christina L. Gardner, Devin A. Boyles, Emily L. Cottle, Matthew D. Dunn, Jeneveve D. Lundy, Noah Salama, Katherine J. O’Malley, Ivona Pandrea, Tobias Teichert, Stacey Barrick, William B. Klimstra, Amy L. Hartman, Douglas S. Reed
Summer fun
We spent last Friday on the rivers of Pittsburgh! Lunch and a relaxing afternoon in the sun while exploring the city onboard a Rivers of Steel boat. Check out our photo gallery here.
Milestones
We hit a lot of milestones this summer!
Maddy passed her comprehensive exam in July! She is now officially a PhD candidate.
Kaleigh passed her comprehensive exam in June! This is taken at the end of the 1st year.
As of August 1, Cindy was promoted to Research Assistant Professor (RAP) and moved into her own space!
Join our team!
We have a job posting for a Research III Technician position to assist us with rodent work across multiple projects. No previous BSL-3 or virology experience needed. Rodent handling experience is required.
We are also actively seeking post-doctoral candidates. We have positions available in several project areas. Email me to find out more.
Scialog Fellow
I’m excited to be named as a Scialog Fellow for a 3-year assignment to mitigate zoonotic threats. This is something that I would not have been able to apply for pre-tenure (due to need to stay focused) but post-tenure, I can expand in new directions. I hope to be able to interact more with scientists at the USDA and foster collaborative efforts.
Fellows Selected for New Scialog: Mitigating Zoonotic Threats
We also have some very exciting publication news that I hope to be able to announce soon….