The Path Forward

“We are concerned that the proposed NSABB oversight rules are not compatible with the realities of implementation, will not achieve the stated goals of increased safety or security, and will ultimately slow research progress to the overall detriment of pandemic preparedness.”

Virology - The Path Forward

NSABB has proposed changes to virology research that, if enacted, will hinder the research that labs like ours are able to do. Having worked in academic research with emerging viruses for 20+ years now, I am intimately familiar with the local and national regulations that are in place to ensure safety of the lab workers and the public. Safety underlies everything we do. Following rules and regulations is, quite literally, what I do for a living. I fully support the safe conduct of research and believe that it can be done safely and effectively. Its critical that we continue to discover new viruses and understand how they work so that we are not completely unprepared for the next hurdle that nature throws at us. Regulation for regulation sake, however, is not effective and will hinder progress. A rational approach to lab safety is paramount. I’ve worked with biosafety professionals for my entire career, and close collaboration between the scientists and the safety professionals is paramount to maintaining effective oversight of virology research.

CVR Holiday Party 2023

An epic time was had by all (as usual, Paul does a great job!)

Placenta Power-house

Once of the things that Cindy and I organized this past year is a monthly working group of labs working in the area of pathogens and the placenta. We brought in folks from OB/GYN, Pediatrics, CVR, Biological Sciences, Medicine…all over the University and a range from the basic to clinical sciences. There is a small community doing this type of work here at Pitt, but the COVID pandemic resulted in each group working in isolation. So we thought we’d fix that. The first year has been a success. Last Friday, we had an in-person end-of-year get-together. We have plans for growing the program in 2024! Stay tuned!

WashU collaborator visit

Fantastic visit by the Amarasinghe/Leung labs from WashU this past week! Super fun talking science with Gaya and the crew and exploring the city of Pittsburgh! Safder gave a CVR Seminar and we ended the visit with a tour of the Nationality Rooms at the Cathedral of Learning.

Welcome Gia!!!

We welcome a new undergraduate student to the lab this semester! Gia Romano is a sophomore in the Bachelor’s in Public Health (BSPH) program. This is a new undergraduate degree program for the school. We are excited to welcome Gia to our lab! Gia is currently learning the basics of an academic research lab, including fun like breeding mice.

Gia describes herself:

New Jersey transplant. Usually found listening to music, watching hockey, or stress baking. Possibly all at the same time.

I hope we get the be the recipients of this stress baking!! :-)

NIAID Prototype Pathogen workshop

2 years ago, I was involved in the NIH Prototype Pathogen workshop, the goal of which was to lay out gaps in knowledge and research priorities for prototype viruses from viral families that NIAID wants to emphasize. Peter Myler (Seattle Children’s) and I chaired the Bunyavirales group. This means we needed to address 4 viral families (Peribunyaviridae, Nairoviridae, Hantaviridae, and Phenuiviridae). This is a difficult task due to the diversity of the Bunyavirales. For those of you that are taxonomically astute, note that I did not list the arenaviridae because they were considered by another group. :-)

We assembled a group of subject matter experts across these families to brainstorm appropriate pathogens and areas of need. We wrote this summary article that was finally published in JID.

Hartman, A.L. and Peter J. Myler. Bunyavirales: Scientific Gaps and Prototype Pathogens for a Large and Diverse Group of Zoonotic Viruses. 2023. The Journal of Infectious Diseases, Volume 228, Issue Supplement 6, 15 October 2023, Pages S376–S389, https://doi.org/10.1093/infdis/jiac338. PMID: 37849397.

There is an entire JID supplement that covers the NIAID Prototype Pathogen approach and has all of the summary articles from the working group. NIAID also wrote about it on their website. Check it out!

Saint Raphael

Had a fantastic time this week at the 10th European Meeting on Viral Zoonoses in Saint Raphael, France. I gave the Richard Elliott Memorial Lecture (eeeek!!) in which I got to show off all the cool work our folks have been doing. I’ve never been to this conference before and Paul and I were two of only 4 Americans at the conference made up of mostly European scientists. It was great to connect with colleagues overseas, especially those from CVR Glasgow! Especially nice to meet new trainees from all over Europe. Here are some photos:

CVR Trainee Day 2023

 

CVR wanted to start an annual Trainee Day so that our trainees (students, post-docs, techs) would have an opportunity to present their work. And added benefit is that we get to see what everyone is working on. Kaleigh, Zach, and Austin all gave talks about their work. This was Zach’s first talk ever, and Austin’s first talk here at Pitt. Very proud of all of them!!